SPIRO BENZAZEPINES USED AS VASOPRESSIN ANTAGONISTS

摘要

The invention is directed to nonpeptide substituted spiroheterobenzazepin e of Formula (I), which are useful as vasopressin receptor antagonists for t reating conditions associated with vasopressin receptor activity such as tho se involving increased vascular resistance and cardiac insufficiency, includ ing congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating con ditions such as hypertension, congestive heart failure, cardiac insufficienc y, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, rena l vasospasm, renal insufficiency, renal failure, diabetic nephropathy, cereb ral edema, cerebral ischemia, stroke, thrombosis, or water retention are als o disclosed.