发明名称 |
ZINC-CONTAINING SUSTAINED-RELEASE COMPOSITION, ITS PREPARATION, AND METHOD FOR PRODUCING THE SAME |
摘要 |
<p>With a simple and high-yield production method, a zinc-containing sustained-release composition capable of stabilizing a physiologically active protein or peptide, typically G-CSF by precipitation and retaining drug efficacy for several days in a living body owing to its sustained releasability is provided. Concretely, a zinc-containing sustained-release composition produced by forming a precipitate by mixing a physiologically active protein or peptide, a water-soluble zinc salt, a water-soluble carbonate and/or a water soluble phosphate aqueous solution. The zinc-containing sustained-release composition may be administered as a zinc-containing sustained preparation by adding a pharmaceutically acceptable additive as is necessary.</p> |
申请公布号 |
EP1620072(B1) |
申请公布日期 |
2008.03.26 |
申请号 |
EP20040725163 |
申请日期 |
2004.04.01 |
申请人 |
LTT BIO-PHARMA CO., LTD. |
发明人 |
KIMURA, MICHIO;ETO, TOMOKO;MIZUSHIMA, YUTAKA |
分类号 |
A61K9/14;A61K9/00;A61K9/19;A61K38/18;A61K38/19;A61K38/20;A61K38/21;A61K38/27;A61K39/395;A61K47/26;A61K47/36;C07K16/24 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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