摘要 |
The disclosure provides compositions and methods relating to or derived f rom anti-activin A binding proteins, including antibodies. In particular emb odiments, the disclosure provides fully human, humanized, and chimeric anti- activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides compr ising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells compr ising such polynucleotides, methods of making such antibodies, antibody frag ments and derivatives and polypeptides, and methods of using such antibodies , antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or condit ions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases. |