PLEUROMUTILIN DERIVATIVES CONTAINING A HYDROXYAMINO- OR ACYLOXYAMINOCYCLOALKYL GROUP

摘要

The present invention relates to compounds of general formula I
wherein
R is hydrogen and R 1 is hydroxy or acyloxy, or
R is acyl and R 1 is hydroxy or acyloxy,
X is sulphur, oxygen or NR 10 , wherein R 10 is hydrogen or (C 1-4 )alkyl;
Y is sulphur or oxygen;
R 2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry;
R4 is hydrogen or (C 1-4 )alkyl;
R 5 is hydrogen or (C 1-4 )alkyl;
R 3 and R 3 ' are hydrogen, deuterium, or halogen;
R 6 , R 7 and R 8 are hydrogen, halogen or deuterium;
m is a number selected from 0 to 4,
n is a number selected from 0 to 10, and
p is a number selected from 0 to 10;
with the proviso that n plus p are at least 1. These compounds are useful as pharmaceuticals, particularly as antimicrobials.