发明名称 |
PROCESS FOR MANUFACTURING VACCINES. |
摘要 |
The present application discloses an improved method for conducting saccharide-protein conjugation reactions using carbodiimide condensation chemistry. Depending on the nature of the saccharide or protein carrier involved, the quality of the conjugate may be improved by adding one of the reaction components slowly to the reaction mixture. Immunogenic compositions are further provided comprising the saccharide-protein conjugates made by the methods disclosed. |
申请公布号 |
MX2007016405(A) |
申请公布日期 |
2008.03.07 |
申请号 |
MX20070016405 |
申请日期 |
2006.06.23 |
申请人 |
GLAXOSMITHKLINE BIOLOGICALS S.A. |
发明人 |
RALPH LEON BIEMANS;PIERRE DUVIVIER |
分类号 |
A61K39/095;A61K39/102;A61K39/116;A61P31/04;C07K17/10 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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