TIZANIDINE SULFATE SALT FORMS AND METHODS OF MAKING AND USING THE SAME

摘要

Disclosed herein is a novel sulfate salt of tizanidine. The invention includes hydrates, solvates, polymorphs, co-crystals, and amorphous forms of tizanidine sulfate salt. Also described herein are novel pharmaceutical compositions comprising tizanidine sulfate salt, methods of making, and related methods of treatment. The present invention provides several dosage forms of tizanidine sulfate salt, such as, controlled release dosage forms.