| 摘要 |
<p>Disclosed is a compound useful as a type I 11 ² hydroxysteroid dehydrogenase inhibitor.
A compound represented by the formula:
a pharmaceutically acceptable salt or solvate thereof,
wherein
R 1 is optionally substituted cycloalkyl, optionally substituted cycloalkenyl or the like,
One of R 2 and R 3 is a group of the formula: -C(=O)-Y-R 4 ,
wherein Y is -NR 9 - or the like,
R 4 is optionally substituted cycloalkyl or the like,
R 9 is hydrogen or optionally substituted alkyl,
W is optionally substituted alkylene,
The other is a group of the formula: -V-R 5 ,
wherein Vis a bond, -O- or the like,
R 6 is hydrogen or optionally substituted alkyl,
R 5 is hydrogen, optionally substituted alkyl or the like,
X is a bond, -S-, -SO- or the like,
U is a bond or optionally substituted alkylene,
R 7 is hydrogen or optionally substituted alkyl,
Zis-S-,-O-or-NR 8 -,
R 8 is hydrogen, optionally substituted alkyl or the like.</p> |
