PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING TRIAZOL DERIVATIVES AS AN ACTIVE INGREDIENTS

摘要

A triazole derivative is provided to inhibit lipid metabolism and energy metabolism effectively by inhibiting the DGAT enzymatic activity inducing metabolic disorders such as obesity and diabetes during lipid metabolism effectively, thereby being usefully used as a therapeutic agent of the metabolic disorders. A pharmaceutical composition for preventing and treating a metabolic disorder selected from the group consisting of fatty liver, obesity, arteriosclerosis and diabetes comprises a triazole derivative represented by the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient. In the formula(1), R1 is H or C1-6 alkoxy; R2 is H; R3 is H or C3-5 branched alkyl(in case the branched alkyl being iso-butyl, a nuclear carbon atom from which methyl is branched is covalently bonded to a number 4 nitrogen of a 1,2,4-triazole ring to form a 6-membered ring and R6 constitutes the nuclear carbon); R4 is H, C1-3 alkyl, or C1-6 alkoxy; R5 is H or benzoxy; R6 is phenyl which may be substituted by halogen, C1-3 alkyl, C1-4 alkoxy or C3-5 branched alkyl(in case of the branched alkyl being iso-butyl, R6 is the nuclear carbon and covalently bonded to the number 4 nitrogen of the 1,2,4-triazole ring); and R7 is H, phenyl, C1-4 linear alkyl, C3-5 branched alkyl, hydroxy, halogen or amino. In the composition, the pharmaceutically acceptable salt of the triazole derivative is in the form of an addition salt formed by a free acid such as an organic acid or an inorganic acid. Further, the inorganic acid is one selected from a group consisting of HCl, HBrO3, H2SO4 and H3PO4.