| 摘要 |
It is proved that hematoporphyrine derivatives (HpD) may be activated not only by visible or ultraviolet light, but also by electromagnetic oscillations of shorter wave length. While irradiating HpD solutions of different concentration with 405 nm light, we can see a visible crimson fluorescence. If at first HpD solutions (1 ml, 0,00001-0,0008 mg/ml) are irradiated by gamma rays (2 Gy, source - 60Co),and then are irradiated by 405 nm blue light, the fluorescence disappears. If to cover the said HpD solutions with calcium soda- lime glass at the time of gamma rays action, the fluorescence remains. The rats that were vaccinated with glioma C6, after injection of HpD and affecting the tumours with small gamma ray dose, a statistically reliable cured tumour regression was observed. During the time of irradiation the covered with calcium soda lime glass tumour growth was not impeded and the effect of treatment would disappear. The results let come to the conclusion that HpD is activated by those ionizing radiation spectrum rays that correspond positrons annihilation gamma quantum line 0,511 MeV in 60Co energetical gamma spectrum. With quantum of this energy, to activate HpD, only 0,020,2 Gy gamma ray dose is needed. |
