HSPA1A AS A MARKER FOR SENSITIVITY TO KSP INHIBITORS

摘要

The present invention relates to methods for predicting a response to treatment with a kinesin spindle protein inhibitor using heat shock protein 70, isoform Ala, also known as HSPAIa, as a marker for sensitivity to the kinesin spindle protein (KSP) inhibitors. Method are provided for predicting a response to treatment with a kinesin spindle protein inhibitor of a first mammal in need thereof comprising determining an amount of HSPAIa mRNA transcript produced by said first mammal, wherein the amount of said HSPAIa mRNA transcript produced by said first mammal is indicative of said mammal's sensitivity to said kinesin spindle protein inhibitor.