PHARMACEUTICAL FORMULATION COMPRISING DONEPEZIL

摘要

The present invention relates to a pharmaceutical composition comprising 2,3- dihydro-5,6-dimethoxy-2-[[1 -(phenylmethyl)-4-piperidinyl]methyl]-1 H-i nden-1 -one, herein after referred to as Donepezil, or a pharmaceutically ac ceptable salt thereof, for treating of Alzheimer's disease and senile dement ia. The present invention also relates to a manufacturing process for the pr eparation of Donepezil tablets containing and retaining polymorphic Form I o f Donepezil hydrochloride. This composition also discloses the use of the ex cipients that ensure adequate flowability of a dry blend as well as required content uniformity and drug release rate of the final product.