摘要 |
Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(-O) or of formula C(-O)NH(OH); R<SUB>1 </SUB>represents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(-O), a hydroxy or amino group; R<SUB>2 </SUB>represents a radical of formula R<SUB>10</SUB>-(X)<SUB>n</SUB>-(ALK)<SUB>m</SUB>- wherein R<SUB>10 </SUB>represents hydrogen, or an optionally substituted c<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, C<SUB>2</SUB>-C<SUB>6 </SUB>alkenyl, C<SUB>2</SUB>-C<SUB>6 </SUB>alkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C<SUB>1</SUB>-C<SUB>6 </SUB>alkylene, C<SUB>2</SUB>-C<img id="CUSTOM-CHARACTER-00001" he="2.46mm" wi="1.44mm" file="US07323596-20080129-P00001.TIF" alt="custom character" img-content="character" img-format="tif"/>6 ?alkenylene, or C<SUB>2</SUB>-C<SUB>6 </SUB>alkynylene radical, and may be interrupted by one or more non-adjacent NH-, -O- or S- linkages, X represents NH-, -O- or S-, and m and n are independently 0 or 1; R<SUB>3 </SUB>represents hydrogen, C<SUB>1</SUB>-C<SUB>6</SUB>alkyl, or benzyl; and R<SUB>4 </SUB>is as defined in the specification.
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