| 摘要 |
The invention relates to biological microbeads, and in certain embodiments, to the use thereof in flow-cytometric applications. Biological microbeads are fixed cells that may be surface-modified with proteins or other molecules that have specific binding properties. These surface-bound proteins may bind to target compounds bearing fluorescent labels that facilitate detection by flow cytometry. Provided are compositions and methods for the use of biological microbeads as an inexpensive alternative to synthetic microbeads for in an extensive number of flow-cytometric applications, including quantitative PCR, detection of nucleases, detection of proteases, and immunoassays.
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