发明名称 |
Tumor-specific promotor and use thereof |
摘要 |
A promoter domain of 1816 bp or 441 bp in the upstream side of exon 1B of IAI.3B gene has a specifically high promoter activity in ovarian cancer cells. An adenovirus having this promoter domain inserted in the E1 domain thereof exhibits a specifically high cell proliferation inhibitory effect on ovarian cancer cells. Thus, it is efficacious in gene therapy for ovarian cancer.
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申请公布号 |
US7321030(B2) |
申请公布日期 |
2008.01.22 |
申请号 |
US20040489258 |
申请日期 |
2004.10.04 |
申请人 |
THE NEW INDUSTRY RESEARCH ORGANIZATION |
发明人 |
HAMADA KATSUYUKI |
分类号 |
C07H21/04;A61K35/76;A61K48/00;C12N7/01;C12N15/36;C12N15/85;C12N15/861 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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