发明名称 |
2'-arabino-fluorooligonucleotide N3'->P5' phosphoramidates: their synthesis and use |
摘要 |
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2'-arabino-fluoronucleoside and an internucleoside 3'-NH-P(-O)(OR)-O-5' linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2'-arabino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.
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申请公布号 |
US7321029(B2) |
申请公布日期 |
2008.01.22 |
申请号 |
US20030181823 |
申请日期 |
2003.05.29 |
申请人 |
GERON CORPORATION |
发明人 |
GRYAZNOV SERGEI;SCHULTZ RONALD G. |
分类号 |
C07H21/00;C07G3/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/02;C07H21/04;C12Q1/68 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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