| 摘要 |
The present invention relates to 1,3-dioxoisoindole derivatives of Formula (1) or pharmaceutically acceptable salts thereof, a preparation method thereof and use thereof as a T-type calcium channel antagonist, based on the fact that 1,3-dioxoisoindole derivatives of Formula (1) show selective antagonistic activity against T-type calcium channel, thus being effective in treating brain diseases, cardiac diseases and neurogenic pains: wherein R<SUB>1 </SUB>is a phenyl or a benzyl group, optionally substituted with a moiety selected from the group consisting of a halogen atom, a C<SUB>1</SUB>-C<SUB>6 </SUB>alkoxy, a C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl, and a cyano group; R<SUB>2 </SUB>is a heterocyclic group selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl, and piperazinyl groups, wherein the heterocyclic group is optionally substituted with a C<SUB>1</SUB>-C<SUB>6 </SUB>alkyl group; and n is 1 or 2.
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