发明名称 |
RECOMBINANT HIV-1 GP120 IMMUNOGEN WITH THREE DIFFERENT V3 LOOPS FROM VIRUSES OF DIFFERENT CLADES |
摘要 |
<p>A novel immunogenic HIV-1 Env, particularlygp120, DNA construct is disclosed in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. Preferably, each replacement V3 loop is a consensus sequence of V3 of a different clade. Such constructs are useful as immunogens as each presents three independent V3 epitopes, so that the immunized subject generates a more broadly reactive neutralizing antibody response than with conventional gp120 or V3 DNA or polypeptide immunogens. Also disclosed are methods of using the DNA construct to immunize a mammal, preferably a human, particularly in a priming regiment in which the DNA immunogen is followed by administration of a V3 fusion protein boosting immunogen.</p> |
申请公布号 |
WO2008005929(A2) |
申请公布日期 |
2008.01.10 |
申请号 |
WO2007US72660 |
申请日期 |
2007.07.02 |
申请人 |
NEW YORK UNIVERSITY;UNIVERSITY OF MASSACHUSETTS;ZOLLA-PAZNER, SUSAN;LU, SHAN;WANG, SHIXIA |
发明人 |
ZOLLA-PAZNER, SUSAN;LU, SHAN;WANG, SHIXIA |
分类号 |
A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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