| 发明名称 |
RECOMBINANT ANTIBODIES AND IMMUNOCONJUGATES TARGETED TO CD-22 BEARING CELLS AND TUMORS |
| 摘要 |
Methods and compositions relating to recombinant anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells. |
| 申请公布号 |
EP0970227(B1) |
申请公布日期 |
2008.01.09 |
| 申请号 |
EP19980912977 |
申请日期 |
1998.03.19 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
FITZGERALD, DAVID;PASTAN, IRA;MANSFIELD, ELIZABETH;KREITMAN, ROBERT |
| 分类号 |
C12N15/70;G01N33/53;A61K38/00;A61K39/395;A61K45/00;A61K47/48;A61K48/00;A61K51/10;A61P35/00;C07K16/28;C07K19/00;C12N1/21;C12N15/09;C12N15/62;G01N33/574;G01N33/577;G01N33/68 |
主分类号 |
C12N15/70 |
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