FUSION PROTEIN OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AS PRRS VACCINE

摘要

A PE-PQGAB-K3 fusion protein is provided which shows antigen-specific allergy effect and has the excellent protective function when being infected by PQGAB. A PE-PQGAB-K3 fusion protein comprises a chimeric polypeptide containing N-terminal portions of PRRSV ORF5 and ORF6 structure proteins; a portion of Pseudomonas exotoxin A binding and translocation domain; and a carboxyl terminal domain containing KDEL-KDEL-KDEL(K3) sequence. A pharmaceutical composition used as a vaccine comprises the PE-PQGAB-K3 fusion protein and a pharmaceutically acceptable carrier comprising an adjuvant selected from the group consisting of Freund's FCA, Alum, FIA, and mannide'mono-oleate emulsifier(ISA720 or ISA206).