发明名称 |
Beta secretase exosite binding peptides and methods for identifying beta secretase modulators |
摘要 |
The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
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申请公布号 |
US7314726(B2) |
申请公布日期 |
2008.01.01 |
申请号 |
US20030685898 |
申请日期 |
2003.10.15 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
KORNACKER MICHAEL G.;COPELAND ROBERT A.;HENDRICK JOSEPH;LAI ZHIHONG;MAPELLI CLAUDIO;WITMER MARK RICHARD;MARCINKEVICIENE JOVITA;METZLER WILLIAM;LEE VING;RIEXINGER DOUGLAS JAMES |
分类号 |
G01N33/53;C07K1/04;C07K7/06;C07K7/08;C07K14/16;C07K14/47 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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