SOLUBLE STABILIZED TRIMERIC HIV ENV PROTEINS AND USES THEREOF

摘要

This invention provides a protein comprising (a) a first polypeptide whic h comprises consecutive amino acids, the sequence of which corresponds to th e sequence of a modified gpl20 envelope polypeptide portion of a gpl40 envel ope of (i) an HIV-I KNH1144 isolate, or a quasi-species thereof, or (ii) an HIV-I 5768.4 isolate, or a quasi-species thereof; and (b) a second polypepti de which comprises consecutive amino acids, the sequence of which correspond s to the sequence of a modified gp41 ectodomain polypeptide portion of the g pl40 envelope of (i) the HIV-I KNHl144 isolate or such quasi-species thereof , or (ii) the HIV-I 5768.4 isolate or such quasi-species thereof. This inven tion also provides nucleic acids encoding such proteins, vectors, host cells and compositions thereof. Also provided are trimeric complexes ("trimers") of these proteins and methods of using such trimers to combat HIV-I infectio n.