beta-catenin oligonucleotide microchip and method for detecting beta-catenin mutations employing same

摘要

The present invention relates to a beta-catenin oligonucleotide microchip for detecting mutation in the mutational hot spot regions of beta-catenin gene, a manufacturing process thereof and a method for detecting the beta-catenin mutation employing same, wherein specific oligonucleotides are selectively designed to detect various missense mutations and in-frame deletion at the mutational hot spots of beta-catenin gene. The beta-catenin oligo chip of the present invention can be used in studies to detect beta-catenin mutations and unravel the signal transduction mechanism and tumorigenesis related to beta-catenin gene.