LATERAL FLOW IMMUNOASSAY WITH ENCAPSULATED DETECTION MODALITY
摘要
A lateral flow immunoassay featuring encapsulated metal particles. The encapsulated particles may use SERS nanotags as the detection modality. The use of encapsulated particles as a detection modality, in particular encapsulated SERS tags increases the sensitivity of an LFI prepared for visual reading and introduces the ability to obtain substantially more sensitive qualitative results or quantitative results through the analysis of a SERS spectrum read from an LFI prepared in accordance with the present invention. The use of SERS as detection modality also enhances the ability of an LFI device to be used for a multiplexed test. Other aspects of the present invention include LFI devices specifically configured to test whole blood, a reader for the detection and interpretation of a multiplexed assay and the hardware and software components used to implement the reader.
申请公布号
WO2007090058(A3)
申请公布日期
2007.12.21
申请号
WO2007US61136
申请日期
2007.01.26
申请人
OXONICA, INC.;NATAN, MICHAEL;CROMER, REMY;DOERING, WILLIAM;CORISH, PETER
发明人
NATAN, MICHAEL;CROMER, REMY;DOERING, WILLIAM;CORISH, PETER