发明名称 |
DPH2 GENE DELETION MUTANT AND USES THEREOF |
摘要 |
<p>Diphtheria and Pseudomonas infections are very common worldwide. The toxins involved in the pathogenesis of those diseases act by inactivating the elongation factor-2 (EF-2), therefore blocking protein synthesis and leading to cell death. Diphthamide formation on EF-2 is a prerequisite step in the inactivation of EF-2, and Dph proteins have been identified as modulating this process. The present application concerns Dph2 deletion mutant genes and proteins and their uses in vitro and in vivo.</p> |
申请公布号 |
WO2007143858(A1) |
申请公布日期 |
2007.12.21 |
申请号 |
WO2007CA01087 |
申请日期 |
2007.06.18 |
申请人 |
CARUSO, MANUEL;ROY, VINCENT |
发明人 |
CARUSO, MANUEL;ROY, VINCENT |
分类号 |
C12N15/12;A61K31/7088;A61K35/12;A61K38/17;A61K48/00;A61P31/04;A61P39/00;C07K14/47;C12N5/00;C12N7/01;C12N15/63;C12P21/00;C12Q1/04;C12Q1/18 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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