ENTERIC COATED GRANULE AND METHOD FOR PREPARING THE SAME

摘要

An enteric coated granule is provided which is able to inhibit dissolution into water although having a small amount of coating. And a method for preparing the same is provided. An enteric coated granule comprises: a raw granule, or a granule comprising a raw granule and at least one layer covering the raw granule; a first enteric layer covering the raw granule or the granule comprising a first hydroxypropylmethyl cellulose acetate succinate(HPMCAS); and a second enteric layer formed over the first enteric layer comprising a second hydroxypropylmethyl cellulose acetate succinate(HPMCAS) and is characterized in that a solubility pH value of the second HPMCAS of the second enteric layer is lower than a solubility pH value of the first HPMCAS of the first enteric layer. A method for preparing an enteric coated granule comprises the steps of: (a) covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first hydroxypropylmethyl cellulose acetate succinate(HPMCAS) to form a first enteric layer; and (b) forming a second enteric layer over the first enteric layer by using an enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.