发明名称 |
Novel processes for preparing sertraline hydrochloride crystalline forms |
摘要 |
<p>The present invention discloses novel and improved processes for preparation of sertraline hydrochloride crystalline form II. Thus, for example, sertraline free base is dissolved in isoamyl alcohol at 25 - 30°C, pH of the mass is adjusted to 2.0 with conc. hydrochloric acid (36%) at 25 - 30°C and then stirred for 14 hours at 25 - 30°C. Filtered the solid and dried at 65°C for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form 1.</p> |
申请公布号 |
EP1862447(A2) |
申请公布日期 |
2007.12.05 |
申请号 |
EP20070005549 |
申请日期 |
2007.03.19 |
申请人 |
HETERO DRUGS LIMITED |
发明人 |
REDDY, BANDI PARTHASARADHI;REDDY, KURA RATHNAKAR;REDDY, RAPOLU RAJI;REDDY, DASARI MURALIDHARA;REDDY, KESIREDDY SUBASH CHANDER |
分类号 |
C07C209/84;C07C211/42 |
主分类号 |
C07C209/84 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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