发明名称 |
REMEDY FOR DISEASE ASSOCIATED WITH APOPTOTIC DEGENERATION IN OCULAR CELL TISSUE WITH THE USE OF SIV-PEDF VECTOR |
摘要 |
It is intended to provide a novel method of treating a diseases associated with apoptotic degeneration in an ocular cell tissue by effectively administering pigment epithelium-derived factor (PEDF). Attentions are focused on PEDF as a novel means of preventing neural ganglion death which is the final pathological stage in glaucoma. Further, attentions are paid to an SIV vector as an effective method of delivering PEDF and an SIV-PEDF vector is constructed. When the SIV-PEDF vector is subretinally administered to an ischemic reperfusion model and an NMDA-induced model, it is observed that neural ganglion death is remarkably inhibited. Thus, it is found out that the SIV-PEDF vector is efficacious as a drug for treating a diseases associated with apoptotic degeneration in an ocular cell tissue such as glaucoma.
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申请公布号 |
KR20070114761(A) |
申请公布日期 |
2007.12.04 |
申请号 |
KR20077021731 |
申请日期 |
2007.09.21 |
申请人 |
DNAVEC CORPORATION |
发明人 |
MIYAZAKI MASANORI;YONEMITSU YOSHIKAZU;IKEDA YASUHIRO;SUEISHI KATSUO;TABATA TOSHIAKI;IIDA AKIHIRO;UEDA YASUJI;HASEGAWA MAMORU |
分类号 |
A61K48/00;A61K38/00;A61P27/02 |
主分类号 |
A61K48/00 |
代理机构 |
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主权项 |
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