PROCESS FOR THE PREPARATION OF OPTICALLY PURE OR ENRICHED RACEMIC TETRALONE

摘要

A PROCESS FOR PRODUCING SUBSTANTIALLY OPTICALLY PURE SERTRALINE UTILIZES CHROMATOGRAPHIC SEPARATION ON A SOLID STATIONARY CHIRAL PHASE OF SPHERICAL CLAY PARTICLES HAVING AN INTERLAYER CONTAINING AN OPTICALLY PURE METAL-ORGANIC COMPLEX, AND A LIQUID MOBILE PHASE PREFERABLY CONTAINING AT LEAST METHYL ACETATE. THE LIQUID MOBILE PHASE IS PREFERABLY FREE OF ACETONITRILE. THE PROCESS IS OPERABLE AT TEMPERATURE ABOVE 40°C.