| 摘要 |
Described are mutant Na<SUB>v</SUB>1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Na<SUB>v</SUB>1 sodium channel alpha-subunit, methods for determining a Na<SUB>v </SUB>1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with a sodium channel mutation, and methods of identifying a compound that modulates mutant Na<SUB>v</SUB>1.7 sodium channels. Other materials, compositions, articles, devices, and methods relating to mutant Na<SUB>v</SUB>1.7 sodium channels are also described herein.
|
