发明名称 |
STELLENSPEZIFISCHE LISTERIA-INTEGRATIONSVEKTOREN UND VERFAHREN ZU DEREN VERWENDUNG |
摘要 |
Site-specific Listeria integration vectors and methods for their use are provided. The subject vectors include a bacteriophage integrase gene and a bacteriophage attachment site, where in many embodiments the bacteriophage that is the source 0 of these elements is a listeriophage. In certain embodiments, the subject vectors further include a multiple cloning site, where the multiple cloning site may further include a polypeptide coding sequence, e.g., for a heterologous antigen. The subject vectors and methods find use in a variety of different applications, including the study of Listeria species and the preparation of Listeria vaccines. |
申请公布号 |
DE60311252(T2) |
申请公布日期 |
2007.11.22 |
申请号 |
DE2003611252T |
申请日期 |
2003.04.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PORTNOY, DANIEL A.;CALENDAR, RICHARD;LAUER, PETER M. |
分类号 |
C12N15/09;C12N15/74;A61K39/02;A61K39/07;A61K48/00;A61P31/04;C12N1/21;C12R1/01 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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