| 摘要 |
The invention relates to compounds of formula (I) and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. Thi s invention also relates to a method of using such compounds in the treatmen t of hyperproliferative diseases and autoimmune diseases in mammals, especia lly humans, and to pharmaceutical compositions containing such compounds.</S DOAB>
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