摘要 |
The present invention describes an efficient and economical process for the preparation of a 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative that is useful for the large scale production of material for preclinical and clinical use. The process of the present invention represents a convergent approach to generate the 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative in high overall yield. The compound made by the process of the invention is an inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and is therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. |
申请人 |
MERCK & CO., INC.;BELYK, KEVIN, MICHAEL;DORNER, BENJAMIN;HARTNER, FREDERICK;YOSHIKAWA, NAOKI;LIMANTO, JOHN;TAN, LUSHI;VAZQUEZ, ENRIQUE;PAYACK, JOSEPH |
发明人 |
BELYK, KEVIN, MICHAEL;DORNER, BENJAMIN;HARTNER, FREDERICK;YOSHIKAWA, NAOKI;LIMANTO, JOHN;TAN, LUSHI;VAZQUEZ, ENRIQUE;PAYACK, JOSEPH |