发明名称 |
ANTIBODIES FOR THE DETECTION OF BACILLUS ANTHRACIS AND VACCINE AGAINST B. ANTHRACIS INFECTIONS |
摘要 |
35 Abstract The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis. |
申请公布号 |
WO2007125089(A2) |
申请公布日期 |
2007.11.08 |
申请号 |
WO2007EP54137 |
申请日期 |
2007.04.27 |
申请人 |
ETH ZUERICH;SCHWEIZERISCHES TROPENINSTITUT;WERZ, DANIEL B.;SEEBERGER, PETER H.;TAMBORRINI, MARCO;PLUSCHKE, GERD |
发明人 |
WERZ, DANIEL B.;SEEBERGER, PETER H.;TAMBORRINI, MARCO;PLUSCHKE, GERD |
分类号 |
A61K39/385;A61K47/48 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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