| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new azulene derivative having excellent serum cholesterol-reducing activities and useful as a serum cholesterol-reducing agent. <P>SOLUTION: The azulene derivative is a compound represented by general formula (I) [wherein, R<SP>1</SP>, R<SP>2</SP>and R<SP>3</SP>are the same or different, and each an azulene ring which may have a substituent or a benzene ring which may have a substituent (with the proviso that one of R<SP>1</SP>, R<SP>2</SP>and R<SP>3</SP>is always the azulene ring which may have a substituent); A is -(CH<SB>2</SB>)<SB>m</SB>-, -O-(CH<SB>2</SB>)<SB>n</SB>-, -CH=CH-(CH<SB>2</SB>)<SB>n</SB>-, -CH(OH)-(CH<SB>2</SB>)<SB>n</SB>- or -C(=O)-(CH<SB>2</SB>)<SB>n</SB>- (wherein, m is an integer of 1-5; and n is an integer of 1-4)] or a pharmaceutically acceptable salt thereof. <P>COPYRIGHT: (C)2008,JPO&INPIT |
