SEPARATION OF CONJUGATED AND UNCONJUGATED COMPONENTS
摘要
The invention is based on the use of a basic reagent under basic conditions to separate conjugated saccharide from unconjugated components in a sample, e.g. a vaccine, by precipitation of the conjugated saccharide. The invention allows rapid and quantitative separation of conjugated and conjugated components, which may be exploited in analytical methods for quantifying unconjugated saccharide or carrier. Therefore, the separation of conjugated and unconjugated components using the invention may be advantageously combined with a quantitative saccharide or carrier analysis to provide improved quality control for conjugate vaccines.
申请公布号
WO2007122512(A2)
申请公布日期
2007.11.01
申请号
WO2007IB01855
申请日期
2007.03.21
申请人
NOVARTIS VACCINES AND DIAGNOSTICS SRL;BERTI, FRANCESCO;GALLETTI, BRUNO;PARENTE, PIERINO;COSTANTINO, PAOLO
发明人
BERTI, FRANCESCO;GALLETTI, BRUNO;PARENTE, PIERINO;COSTANTINO, PAOLO