COMPOSITIONS AND METHODS FOR SUPPRESSION OF AMYLOID PLAQUE FORMATION ASSOCIATED WITH NEURODEGENERATIVE DISORDERS.
摘要
<p>The invention provides a method for reducing or inhibiting net beta-amyloid peptide production and amyloid plaque formation associated with Alzheimer's Disease by administering to a subject an amount of a netrin-1 polypeptide, wherein the netrin-1 polypeptide comprises an amino acid sequence that a) binds to a naturally occurring APP protein and b) inhibits Aß peptide production. A netrin-1 polypeptide has an amino acid sequence sufficient for specific binding of the netrin-1 polypeptide to the APP protein. A netrin-1 polypeptide can mimic netrin-1 -mediated signal transduction by altering the localization, protein-protein binding and/or enzymatic activity of an intracellular protein involved in an APP signal pathway. The invention also provides a method for reducing or inhibiting amyloid plaque formation associated with Alzheimer's Disease by administering to a subject an amount of a netrin-1 therapeutic, wherein the netrin-1 therapeutic comprises an amino acid sequence that a) binds to a naturally occurring APP protein and b) inhibits Aß<I/>peptide production.</p>
申请公布号
WO2007120912(A2)
申请公布日期
2007.10.25
申请号
WO2007US09394
申请日期
2007.04.16
申请人
BUCK INSTITUTE FOR AGE RESEARCH;CENTRE LEON-BERARD;MEHLEN, PATRICK;CALHEIROS-LOURENCO, FELIPE;GALVAN, VERONICA;BREDESEN, DALE, E.
发明人
MEHLEN, PATRICK;CALHEIROS-LOURENCO, FELIPE;GALVAN, VERONICA;BREDESEN, DALE, E.