MUTANT POLYPEPTIDE HAVING EFFECTOR FUNCTION

摘要

A mutant polypeptide of the invention contains an Fc region in which the second amino acid from a glycosylation site to the N terminus side in the Fc region is replaced with a cystein residue. The Fc region is preferably an Fc region of human IgG. The mutant polypeptide of the invention may have an N-linked sugar chain at the glycosylation site of the Fc region. Further, the mutant polypeptide of the invention may be a polypeptide molecule in which a polypeptide site other than the Fc region recognizes a molecule present on the surface of a human cell.