| 摘要 |
<p>u A method for the production of a non-hygroscopic powder composition (I) involves spray drying (without a spray-drying adjuvant) an aqueous solution containing initially hygroscopic product(s) with a glass transition point (Tg) of 10-110[deg]C (II) and a cryogenic fluid (III), preferably a food-grade fluid or a mixture of fluids, especially carbon dioxide, nitrogen or liquid air, said solution being obtained by dissolving (III) in an aqueous solution of (II). u Independent claims are included for (1) a method for the continuous production of (I) by (a) heating the initial aqueous solution of (II) (preferably lactulose) to 50-85 (preferably 65-80) [deg]C, (b) dissolving cryogenic fluid (III) in the hot solution at a pressure of 1-20 x 10 5> (preferably 4-12 x 10 5>) Pa, (c) simultaneously spraying an anti-agglomerant (IV) and the aqueous solution to give a pulverised mixture, (d) drying the mixture by atomisation with hot air at 100-250 (preferably 115-150) [deg]C to give a partly dried and non-stabilised hygroscopic powder which is then subjected to primary stabilisation followed by (e) secondary stabilisation (2) powder compositions (I) obtained by the above methods (3) a non-hygroscopic lactulose powder obtained by these methods, possibly as a mixture with other products with nutritional and/or therapeutic properties (4) a non-hygroscopic lactulose powder composition which is non-sticky in a temperature range of 10-45 (preferably 20-38) [deg]C and also has a water content of less than 7 (preferably 1-4) wt% .</p> |
