LOAD INDEPENDENT INDEX OF DIASTOLIC FUNCTION

摘要

The present invention is based in part on the surprising discovery that a load independent index of diastolic function (LIIDF) can be obtained from a determination of peak driving force (kx₀) and peak-resistive force (cE_peak) in a subject, and that kx_o vs. cE_peak, maintain a load independent and linear relationship Similarly, a non model-based approach using a value for duration of the E-wave (E_dur) from the E-wave, and a value for a deceleration time-acceleration time (DT-AT) of the E-wave can be used to derive a linear function describing the relationship of Edur to DT-AT, which also provides the analogous LIIDF The LIIDF can be obtained using data obtained from a variety of imaging modalities, including noninvasive and invasive modalities.