METHOD FOR PRODUCTION OF CARBOXYLIC ACID USING METHANOL-UTILIZING BACTERIUM

摘要

Disclosed is a method for producing a carboxylic acid by employing a fermentation process which comprises culturing a methanol-utilizing bacterium capable of producing the carboxylic acid in a liquid culture medium containing methanol and a counter ion to produce and accumulate the carboxylic acid in the culture medium. In the method, a substance containing methanol and the counter ion is fed to the culture medium by employing a feeding culture process, so that the total ionic strength in the fermentation culture medium can be maintained at a given level or lower.