摘要 |
<p>Bases of porous tablets for subsequent filling with active pharmaceutical ingredient are made with known processes and are composed only of excipients used in pharmacy that are not soluble in organic solvents, in contact with these solvent do not disintegrate, and are then filled by use of organic solvent solution of active pharmaceutical ingredient and then dried. Excipients are lactose and/or SiO<SUB>2</SUB> and/or with SiO<SUB>2</SUB> modified microcrystalline cellulose in different proportions. Organic solvents in which active pharmaceutical ingredient is dissolved are heptane, isobutyl acetate, isopropyl acetate, methyl acetate, 3-methyl -1-butanol, methylethylketone, methylisobutylketone, 2-methyl-l-propanol, pentane, 1/pentanol, 1- propanol, 2-propanol, propyl acetate, acetic acid, acetone, anisole, 1-butanol, 2-butanol, buthyl acetate, tert-butylmethyl ether, cumene, dimethyl sulphoxide, ethanol, ethyl acetate, ethyl ether, ethyl formate, formic acid, acetonitrile, chlorobenzene, chloroform, cyclohexane 1,2- dichloroethene, dichloromethane, 1,2-dimetoxyethane, N,N-dimethylacetamide, N5N- dimethylformamide, 1,4-dioxane, 2-etoxyethanol, ethyleneglycol, formamide, hexane, methanol, 2-methohyethanol, methylcyclohexane, N-methylpzrrolidone, nitromethane, pyridine, tetrahydrofuran, toluene, xylene or mixtures of two or more of these listed liquids Tablet bases are immersed into surplus of organic solution of active pharmaceutical ingredient. This solution can be added into each tablet separately usindg appropriate dosing device preferentially pipette in the way that tablet absorbs whole amount of solution added.</p> |