Catalytically inactive enzymes for affinity binding

摘要

Provided is a catalytically-inactive, dual-specificity phosphatase (dsPTP) or peptidomimetic affinity capture molecule attached to a matrix, for binding a phosphorylated polypeptide. The invention further provides a method for removing a phosphorylated polypeptide from a sample using the composition and kits useful in the practice of the method.