IMMUNOMODULATING COMPOSITION

摘要

The inventive composition comprises the water-insoluble fraction of cells of the yeast producer of a heterologous hydrophobic protein-cytokine, solubiliser and water, wherein a target hydrophobic protein-cytokine has been synthesises in said producer. In particular the protein-cytokine is embodied in the form of an interleukine-2 (IL-2) and the yeast producer is a Saccharomyces cerevisiae strain deposited in the All-union collection of industrial microorganisms at a No Y-791. Said composition exhibits an immunomodulatory action and can be used in an immune-oriented therapy and, in particular, for treating oncologic, infectious, autoimmune and allergic diseases. A composition containing the water-insoluble fraction of destroyed cells of the heterologous hydrophobic protein-cytokine yeast producer, in which the target hydrophobic protein-cytokine has been synthesised, is also disclosed. Said composition is not active in itself and can be used for producing the immunomodulating composition by adding the solubiliser and water thereto.