发明名称 |
Valproic acid and derivatives thereof as histone deacetylase inhibitors |
摘要 |
The present invention relates to the use of the drug valproic acid and derivatives thereof as inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of those compounds for the manufacture of a medicament for the treatment of diseases which are associated with hypoacetylation of histones or in which induction of hyperacetylation has a beneficial effect for example by induction of differentiation and/or apoptosis in transformed cells.
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申请公布号 |
US2007232696(A1) |
申请公布日期 |
2007.10.04 |
申请号 |
US20070653855 |
申请日期 |
2007.01.17 |
申请人 |
GEORG-SPEYER-HAUS |
发明人 |
GOTTLICHER MARTIN;HEINZEL THORSTEN;GRONER BERND;HERRLICH PETER |
分类号 |
A61K31/22;G01N33/50;A61K31/16;A61K31/19;A61P5/02;A61P35/00;A61P35/02;A61P43/00;C12Q1/68;G01N33/15;G01N33/566;G01N33/574 |
主分类号 |
A61K31/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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