发明名称 |
Novel SH2containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein |
摘要 |
SH2 containing inositol 5'-phosphate (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP isoform expressed in differentiated hematopoietic cells. s-SHIP is also expressed in primitive hematopoietic stem cells, but not in lineage-committed hematopoietic cells. In embryoic stem cells, s-SHIP partners with the adapter protein Grb2 without tyrosine phosphorylation and is present constitutively at the cell membrane. It is postulated that s-SHIP modulates the activation threshold of primitive stem cell populations.
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申请公布号 |
US2007224124(A1) |
申请公布日期 |
2007.09.27 |
申请号 |
US20070726028 |
申请日期 |
2007.03.19 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
KERR WILLIAM G.;NINOS JOHN M. |
分类号 |
C12N15/87;A61K49/00;C07H21/04;C12N5/00;G01N33/53 |
主分类号 |
C12N15/87 |
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