发明名称 Topoisomerase-targeting agents
摘要 The invention provides compounds of formula I or formula II: wherein: the bond represented by - is a single bond or a double bond, and R<SUB>1</SUB>-R<SUB>5</SUB>, X, and Y have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I or II, processes for preparing compounds of formula I or II, intermediates useful for preparing compounds of formula I or II, and therapeutic methods for treating cancer and other topoisomerase related conditions using compounds of formula I or II.
申请公布号 US2007225289(A1) 申请公布日期 2007.09.27
申请号 US20070714680 申请日期 2007.03.06
申请人 RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 发明人 LAVOIE EDMOND J.;RUCHELMAN ALEXANDER L.;LIU LEROY F.
分类号 A61K31/415;C07D491/04 主分类号 A61K31/415
代理机构 代理人
主权项
地址