发明名称 |
DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS |
摘要 |
The present invention relates to certain novel compounds of the formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) E (NR1H3) and/or F (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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申请公布号 |
KR20070094963(A) |
申请公布日期 |
2007.09.27 |
申请号 |
KR20077018460 |
申请日期 |
2007.08.10 |
申请人 |
ASTRAZENECA AB |
发明人 |
BOSTROEM JONAS;BRICKMANN KAY;BROO ANDERS;HOLM PATRIK;JUDKINS ROBERT;LI, LANNA;SANDBERG PERNILLA;SWANSON MARIANNE;WESTERLUND CHRISTER |
分类号 |
C07D275/03;A61K31/54;A61P3/06;C07D417/12 |
主分类号 |
C07D275/03 |
代理机构 |
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代理人 |
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地址 |
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