发明名称 |
MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY |
摘要 |
Methods for detecting and treating Mycobacterium-related diseases including reducing Mycobacterial virulence, reducing RV3133c dimerization, and treating a subject with a Mycobacterial infection using identified compounds are disclosed. Examples of compounds useful in the treatment of Mycobacterium-related diseases include N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde. Further disclosed are methods for identifying agents that interact with a polypeptide in a Mycobacterium cell. |
申请公布号 |
WO2007101274(A2) |
申请公布日期 |
2007.09.07 |
申请号 |
WO2007US63099 |
申请日期 |
2007.03.01 |
申请人 |
THE UAB RESEARCH FOUNDATION;STEYN, ANDRIES, J., C.;MAI, DEBORAH |
发明人 |
STEYN, ANDRIES, J., C.;MAI, DEBORAH |
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