发明名称 |
PRODUCTION OF DICARBOXYLIC ACIDS BY IMPROVED MUTANT STRAINS OF YARROWIA LIPOLYTICA |
摘要 |
The invention concerns a method for producing dicarboxylic acids (DCA) with long hydrocarbon chains, also called diacids, which consists in culturing a mutant strain of Yarrowia lipolytica obtained by mutagenesis directed and more particularly disrupted at least for the POX2, POX3, POX4 and POX5 genes encoding acyl-CoA oxydase, in a medium consisting essentially of an energetic substrate including at least one carbon source and one nitrogen source and in subjecting said strain to a bioconversion substrate selected among n-alkanes of at least 10 carbon atoms, fatty acids of at least 10 carbon atoms, their alkyl esters and natural oils. |
申请公布号 |
EP1828392(A1) |
申请公布日期 |
2007.09.05 |
申请号 |
EP20050826569 |
申请日期 |
2005.12.13 |
申请人 |
INSTITUT FRANCAIS DU PETROLE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) |
发明人 |
NICAUD, JEAN-MARC;THEVENIEAU, FRANCE;LE DALL, MARIE-THERESE;MARCHAL, REMY |
分类号 |
C12P7/40 |
主分类号 |
C12P7/40 |
代理机构 |
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