| 摘要 |
A nonsteroidal antiflammatory analgesic in the form of an alkali metal salt; and a nonaqueous preparation for percutaneous absorption which comprises a support and, superposed thereon, a pressure-sensitive adhesive layer comprising a nonaqueous base compounded with an inorganic acid which is more strongly acidic than the nonsteroidal antiflammatory analgesic in its free state. In the nonaqueous preparation for percutaneous absorption, due to the addition of the inorganic acid, the drug in the form of an alkali metal salt has improved solubility in the nonaqueous base and easily moves to the skin surface. Thus, drug releasability from the nonaqueous preparation for percutaneous absorption and drug penetration through the skin can be improved. Since the inorganic acid has no alcoholic hydroxy group in the structure, the drug does not react with the inorganic acid. The nonaqueous preparation hence undergoes no decrease in drug stability caused by esterification.
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